Phyto-4

• Includes clinically researched botanicals
• Made with high-quality vegan ingredients backed by verifiable science

Perluxan^®   is a clinically studied extract of hops specifically developed to promote joint health. In a randomized, double-blind, placebo-controlled trial of 36 subjects, the benefits of Perluxan^®   on joint comfort reached statistical significance within two hours of the first dose and were sustained over the 14-day period. Perluxan^®   is free of sleep-inducing and phytoestrogenic compounds typically associated with hops extracts.¹   The alpha and iso-alpha acids in Perluxan^®   maintain healthy NF-kappa B-associated expression of COX-2 and cytokines such as IL-6 and TNFα in connective tissue.²   Curcumin complements Perluxan^®   through its extensively characterized effects on cytokine-mediated signal transduction, matrix metalloproteinase (MMP) expression and multiple components of the arachidonic acid cascade.³   Curcumin C3 Complex^®   is the subject of extensive ongoing clinical investigations at numerous hospitals and universities.⁴   Ginger promotes joint health through maintaining healthy cytokine signaling in cartilage and the synovium.⁵   5LOXIN^®   Boswellia serrata   extract provides the highly bioactive triterpenoid AKBA, which supports connective tissue structural composition and comfort through supporting healthy immune responses, 5-lipoxygenase activity and synovial matrix metalloproteinase 3 (MMP-3) levels.^6,7   In a 3-month double-blind, placebo-controlled study of 75 subjects, significant functional support and comfort scores were evident as early as day 7.^8‡