L-theanine, 5-hydroxytryptophan (5-HTP) and melatonin have all been shown to independently improve sleep quality and quantity, and/or lessen anxiety. L-theanine is an amino acid found almost exclusively in tea,1 which influences the central nervous system through a number of mechanisms, primarily by influencing levels of the neurotransmitters dopamine,2 gamma-aminobutyric acid (GABA),3,4 serotonin,5,6 norepinephrine6, and glutamate.7,8 These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning and concentration, as well as decreased anxiety.